About Tetratricopeptide repeat protein 21A
Tetratricopeptide repeat protein 21A (TTC21A) is a protein
from Homo sapiens identified by UniProt accession
Q8NDW8, 1320 residues long.
MolForge cross-references it against 0 known binders and
129 disease associations.
Target properties
| Protein name | Tetratricopeptide repeat protein 21A |
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| UniProt accession | Q8NDW8 |
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| Gene | TTC21A |
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| Organism | Homo sapiens |
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| Length | 1320 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (129)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.59
- non-syndromic male infertility due to sperm motility disorder · score 0.37
- mitochondrial DNA measurement · score 0.15
- cognitive decline measurement · score 0.14
- self reported educational attainment · score 0.11
- brain-derived neurotrophic factor measurement · score 0.11
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- nonpapillary renal cell carcinoma · score 0.07
- partial chromosome Y deletion · score 0.07
- spermatogenic failure 72 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NDW8-F1 | alphafold | PREDICTED | 81.15 | — |
Amino-acid sequence (1320 residues)
MSSNDSSLMA GIIYYSQEKY FHHVQQAAAV GLEKFSNDPV LKFFKAYGVL KEEHIQDAIS DLESIRHHPD VSLCSTMALI YAHKRCEIID REAIQELEYS LKEIRKTVSG TALYYAGLFL WLIGRHDKAK EYIDRMLKIS RGFREAYVLR GWVDLTSDKP HTAKKAIEYL EQGIQDTKDV LGLMGKAMYF MMQQNYSEAL EVVNQITVTS GSFLPALVLK MQLFLARQDW EQTVEMGHRI LEKDESNIDA CQILTVHELA REGNMTTVSS LKTQKATNHV RNLIKALETR EPENPSLHLK KIIVVSRLCG SHQVILGLVC SFIERTFMAT PSYVHVATEL GYLFILKNQV KEALLWYSEA MKLDKDGMAG LTGIILCHIL EGHLEEAEYR LEFLKEVQKS LGKSEVLIFL QALLMSRKHK GEEETTALLK EAVELHFSSM QGIPLGSEYF EKLDPYFLVC IAKEYLLFCP KQPRLPGQIV SPLLKQVAVI LNPVVKAAPA LIDPLYLMAQ VRYYSELENA QSILQRCLEL DPASVDAHLL MCQIYLAQGN FGMCFHCLEL GVSHNFQVRD HPLYHLIKAR ALNKAGDYPE AIKTLKMVIK LPALKKEEGR KFLRPSVQPS QRASILLELV EALRLNGELH EATKVMQDTI NEFGGTPEEN RITIANVDLV LSKGNVDVAL NMLRNILPKQ SCYMEAREKM ANIYLQTLRD RRLYIRCYRE LCEHLPGPHT SLLLGDALMS ILEPEKALEV YDEAYRQNPH DASLASRIGH AYVKAHQYTE AIEYYEAAQK INGQDFLCCD LGKLLLKLKK VNKAEKVLKQ ALEHDIVQDI PSMMNDVKCL LLLAKVYKSH KKEAVIETLN KALDLQSRIL KRVPLEQPEM IPSQKQLAAS ICIQFAEHYL AEKEYDKAVQ SYKDVFSYLP TDNKVMLELA QLYLLQGHLD LCEQHCAILL QTEQNHETAS VLMADLMFRK QKHEAAINLY HQVLEKAPDN FLVLHKLIDL LRRSGKLEDI PAFFELAKKV SSRVPLEPGF NYCRGIYCWH IGQPNEALKF LNKARKDSTW GQSAIYHMVQ ICLNPDNEVV GGEAFENQGA ESNYMEKKEL EQQGVSTAEK LLREFYPHSD SSQTQLRLLQ GLCRLATREK ANMEAALGSF IQIAQAEKDS VPALLALAQA YVFLKQIPKA RMQLKRLAKT PWVLSEAEDL EKSWLLLADI YCQGSKFDLA LELLRRCVQY NKSCYKAYEY MGFIMEKEQS YKDAVTNYKL AWKYSHHANP AIGFKLAFNY LKDKKFVEAI EICNDVLREH PDYPKIREEI LEKARRSLRP
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