About Tetratricopeptide repeat protein 16
Tetratricopeptide repeat protein 16 (TTC16) is a protein
from Homo sapiens identified by UniProt accession
Q8NEE8, 873 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | Tetratricopeptide repeat protein 16 |
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| UniProt accession | Q8NEE8 |
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| Gene | TTC16 |
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| Organism | Homo sapiens |
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| Length | 873 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (16)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.28
- pulse pressure measurement · score 0.21
- mathematical ability · score 0.15
- serum metabolite measurement · score 0.12
- Premature ovarian insufficiency · score 0.11
- prostate carcinoma · score 0.10
- systolic blood pressure · score 0.04
- monocyte count · score 0.02
- basophil count · score 0.02
- colorectal adenocarcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NEE8-F1 | alphafold | PREDICTED | 64.77 | — |
Amino-acid sequence (873 residues)
MTDSDEDALK VDQGPSRDIP KPWVIPAPKG ILQHIFGTSH VFQSICDVKP KVTGLTVPLK VREYYSRGQQ CLEQADWETA VLLFSRALHL DPQLVDFYAL RAEAYLQLCD FSSAAQNLRR AYSLQQDNCK HLERLTFVLY LQGQCLFEQC AFLDALNVFS HAAELQPEKP CFRYRCMACL LALKQHQACL TLITNELKQD TTNADVYIFR ARLYNFLQKP HLCYRDLHSA LLLNPKHPQA RMLLQKMVAQ AQQARQDAGI LAVQGKLQHA LQRINRAIEN NPLDPSLFLF RGTMYRRLQE FDGAVEDFLK VLDMVTEDQE DMVRQAQRQL LLTYNDFAVH CYRQGAYQEG VLLLNKALRD EQQEKGLYIN RGDCFFQLGN LAFAEADYQQ ALALSPQDEG ANTRMGLLQE KMGFCEQRRK QFQKAENHFS TAIRHNPQKA QYYLYRAKSR QLLQNIFGAR QDVATVLLLN PKQPKLSLLM TNLFPGMSVE EVLSTQIAHL ARLQLEQMVE GSLQAGSPQG IVGMLKRHEL ERQKALALQH SWKQGEPLIA TSEELKATPE IPQVKPGSSE GEAEAPEEEE EKEKEKKEEK KSELIPSKVA SLSDSYLDQT SSASSMSFRT TGTSETEMSA ICQEYRSTSA TAVTFSDSSL LKTQSSDSGN NREALSHGPR KIKATQGQRQ SLSKTEPTQS QRRNSSKTKA TIHKRNSSKT KATQSQRRNS SKTRATQGQG QSSSKTEATQ GQRQSSSEIE ATQGPRQEPS KTKTTRSPRQ RPRKVKAARG RSWRPSKVDA TQGRSRGLLR SSTKTEAFYD SNWSLSKTEY AQGQGQRSSK AEGAQGKSQG MSSTSSKAES TWGPSPSLSK TEVDQDLTYY EAV
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