About Golgi-associated RAB2 interactor protein 6
Golgi-associated RAB2 interactor protein 6 (GARIN6) is a protein
from Homo sapiens identified by UniProt accession
Q8NEG0, 241 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | Golgi-associated RAB2 interactor protein 6 |
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| UniProt accession | Q8NEG0 |
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| Gene | GARIN6 |
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| Organism | Homo sapiens |
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| Length | 241 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (13)
Diseases linked to this target (Open Targets).
- smoking status measurement · score 0.20
- heroin dependence · score 0.09
- alcohol dependence · score 0.09
- methamphetamine dependence · score 0.09
- self reported educational attainment · score 0.06
- body mass index · score 0.06
- body weight · score 0.04
- body height · score 0.03
- cognitive function measurement · score 0.03
- fat body mass · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NEG0-F1 | alphafold | PREDICTED | 70.46 | — |
Amino-acid sequence (241 residues)
MEDCCMLPYY TAQSSPAMGM FNTSMGKLQR QLYKGEYTIF RYAPMFESDF IQISKRGEVI DVHNRARMVT MGIVRTSPCL TLPDVMLLAR PAAVCDNARC GPATQKRESP PAEILELTRL LPLMFVKITI HNSVKKQLHL KLATGRSFYL QLCPPSDASE DLFVHWENLV YILRPPVEAY SDTRAILAGN TLDSSVLEEV QRSPVGYAMK FCEEKEQFRI SRLHMNAEMF GSTYCDYTIE I
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