BBSome complex member BBS1 (BBS1)

About BBSome complex member BBS1

BBSome complex member BBS1 (BBS1) is a protein from Homo sapiens identified by UniProt accession Q8NFJ9, 593 residues long. MolForge cross-references it against 0 known binders and 109 disease associations.

Target properties

Protein name	BBSome complex member BBS1
UniProt accession	Q8NFJ9
Gene	BBS1
Organism	Homo sapiens
Length	593 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (109)

Diseases linked to this target (Open Targets).

Bardet-Biedl syndrome 1 · score 0.83
Bardet-Biedl syndrome · score 0.67
retinitis pigmentosa · score 0.63
Retinal dystrophy · score 0.54
genetic disorder · score 0.50
Polydactyly · score 0.46
polydactyly · score 0.46
ciliopathy · score 0.37
Usher syndrome · score 0.33
low density lipoprotein cholesterol measurement · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NFJ9-F1	alphafold	PREDICTED	89.45	—

Amino-acid sequence (593 residues)

MAAASSSDSD ACGAESNEAN SKWLDAHYDP MANIHTFSAC LALADLHGDG EYKLVVGDLG PGGQQPRLKV LKGPLVMTES PLPALPAAAA TFLMEQHEPR TPALALASGP CVYVYKNLRP YFKFSLPQLP PNPLEQDLWN QAKEDRIDPL TLKEMLESIR ETAEEPLSIQ SLRFLQLELS EMEAFVNQHK SNSIKRQTVI TTMTTLKKNL ADEDAVSCLV LGTENKELLV LDPEAFTILA KMSLPSVPVF LEVSGQFDVE FRLAAACRNG NIYILRRDSK HPKYCIELSA QPVGLIRVHK VLVVGSTQDS LHGFTHKGKK LWTVQMPAAI LTMNLLEQHS RGLQAVMAGL ANGEVRIYRD KALLNVIHTP DAVTSLCFGR YGREDNTLIM TTRGGGLIIK ILKRTAVFVE GGSEVGPPPA QAMKLNVPRK TRLYVDQTLR EREAGTAMHR AFQTDLYLLR LRAARAYLQA LESSLSPLST TAREPLKLHA VVQGLGPTFK LTLHLQNTST TRPVLGLLVC FLYNEALYSL PRAFFKVPLL VPGLNYPLET FVESLSNKGI SDIIKVLVLR EGQSAPLLSA HVNMPGSEGL AAA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards