About Coiled-coil domain-containing protein 148
Coiled-coil domain-containing protein 148 (CCDC148) is a protein
from Homo sapiens identified by UniProt accession
Q8NFR7, 591 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Coiled-coil domain-containing protein 148 |
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| UniProt accession | Q8NFR7 |
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| Gene | CCDC148 |
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| Organism | Homo sapiens |
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| Length | 591 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (28)
Diseases linked to this target (Open Targets).
- restless legs syndrome · score 0.36
- ganglion cell inner plexiform layer thickness measurement · score 0.29
- insomnia measurement · score 0.28
- retinal layer thickness measurement · score 0.28
- body fat percentage · score 0.27
- body mass index · score 0.24
- self reported educational attainment · score 0.22
- diastolic blood pressure · score 0.20
- mathematical ability · score 0.19
- hypertension · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NFR7-F1 | alphafold | PREDICTED | 78.93 | — |
Amino-acid sequence (591 residues)
MCAASASPDN LVFHMKNEMR NIKYKPVDYQ QLRALTEAKK LASASAKLKI RKAMLTSKLS KEQTLIKQHK QVWWQEYQRL NEVRCKMESE IKSLLNEENI GNECLCDLTN FEQELSEQQC TYLKNVINPI QQLRADLKYR QHHTLQHSHP HIEFNSMKVL EEVDFVKKQL KTVFERLRLE QQRIENDLSD WSIKILDHSL EEKTNPLSEL PIELESLECP YPDLKSSILS EFYKFTQKYQ KKLQDFNLQL EDIYRNCQLS EEDHWIYQAI LDQYPGDLFG RRTLYLDMLQ RYFPHKSRHD LVEHEKYCDQ YRFAIEQQNI LISNWNKNKK DFIQKAVLTL TEACATHEME SMLAKDKKKQ QELCADLKAK VRQWRAHQEE VARLEMEISA RRREKEEEKE KLWKKKELLQ RAEKKKKIKK YWAKKKQKWQ EMEMRDLQRL EELKKLIAEQ SLKDRERVKY RQELLERRLM EKKEVALQEA HEDKERARRL EALRKQVAVV AQFDPVRMMS DTMASKARMG IEIEEEFILQ KPLFTLNTYN EQQIISDPRL RFELALREAG LHRTLYAKEI LPKISPQKPP RKDMESTVFK I
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