About Kelch repeat and BTB domain-containing protein 8
Kelch repeat and BTB domain-containing protein 8 (KBTBD8) is a protein
from Homo sapiens identified by UniProt accession
Q8NFY9, 601 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Kelch repeat and BTB domain-containing protein 8 |
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| UniProt accession | Q8NFY9 |
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| Gene | KBTBD8 |
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| Organism | Homo sapiens |
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| Length | 601 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (50)
Diseases linked to this target (Open Targets).
- hemoglobin measurement · score 0.35
- reticulocyte count · score 0.33
- intraocular pressure measurement · score 0.32
- reticulocyte measurement · score 0.32
- Red cell distribution width · score 0.29
- blood urea nitrogen measurement · score 0.29
- mean corpuscular hemoglobin concentration · score 0.28
- uric acid measurement · score 0.24
- body height · score 0.24
- serum urea measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NFY9-F1 | alphafold | PREDICTED | 87.83 | — |
Amino-acid sequence (601 residues)
MAASADLSKS SPTPNGIPSS DPASDAMDPF HACSILKQLK TMYDEGQLTD IVVEVDHGKT FSCHRNVLAA ISPYFRSMFT SGLTESTQKE VRIVGVEAES MDLVLNYAYT SRVILTEANV QALFTAASIF QIPSIQDQCA KYMISHLDPQ NSIGVFIFAD HYGHQELGDR SKEYIRKKFL CVTKEQEFLQ LTKDQLISIL DSDDLNVDRE EHVYESIIRW FEHEQNEREV HLPEIFAKCI RFPLMEDTFI EKIPPQFAQA IAKSCVEKGP SNTNGCTQRL GMTASEMIIC FDAAHKHSGK KQTVPCLDIV TGRVFKLCKP PNDLREVGIL VSPDNDIYIA GGYRPSSSEV SIDHKAENDF WMYDHSTNRW LSKPSLLRAR IGCKLVYCCG KMYAIGGRVY EGDGRNSLKS VECYDSRENC WTTVCAMPVA MEFHNAVEYK EKIYVLQGEF FLFYEPQKDY WGFLTPMTVP RIQGLAAVYK DSIYYIAGTC GNHQRMFTVE AYDIELNKWT RKKDFPCDQS INPYLKLVLF QNKLHLFVRA TQVTVEEHVF RTSRKNSLYQ YDDIADQWMK VYETPDRLWD LGRHFECAVA KLYPQCLQKV L
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