Motile sperm domain-containing protein 2 (MOSPD2)

About Motile sperm domain-containing protein 2

Motile sperm domain-containing protein 2 (MOSPD2) is a protein from Homo sapiens identified by UniProt accession Q8NHP6, 518 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Motile sperm domain-containing protein 2
UniProt accession	Q8NHP6
Gene	MOSPD2
Organism	Homo sapiens
Length	518 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

experimental autoimmune encephalomyelitis · score 0.07
metastatic melanoma · score 0.02
neoplasm · score 0.02
infection · score 0.02
infect · score 0.02
cancer · score 0.01
myeloid sarcoma · score 0.01
Infertility · score 0.01
osteosarcoma · score 0.01
Osteoporosis · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NHP6-F1	alphafold	PREDICTED	80.22	—

Amino-acid sequence (518 residues)

MAENHAQNKA KLISETRRRF EAEYVTDKSD KYDARDVERL QQDDNWVESY LSWRHNIVDE TLKMLDESFQ WRKEISVNDL NESSIPRWLL EIGVIYLHGY DKEGNKLFWI RVKYHVKDQK TILDKKKLIA FWLERYAKRE NGKPVTVMFD LSETGINSID MDFVRFIINC FKVYYPKYLS KIVIFDMPWL MNAAFKIVKT WLGPEAVSLL KFTSKNEVQD YVSVEYLPPH MGGTDPFKYS YPPLVDDDFQ TPLCENGPIT SEDETSSKED IESDGKETLE TISNEEQTPL LKKINPTEST SKAEENEKVD SKVKAFKKPL SVFKGPLLHI SPAEELYFGS TESGEKKTLI VLTNVTKNIV AFKVRTTAPE KYRVKPSNSS CDPGASVDIV VSPHGGLTVS AQDRFLIMAA EMEQSSGTGP AELTQFWKEV PRNKVMEHRL RCHTVESSKP NTLTLKDNAF NMSDKTSEDI CLQLSRLLES NRKLEDQVQR CIWFQQLLLS LTMLLLAFVT SFFYLLYS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards