About DnaJ homolog subfamily B member 8
DnaJ homolog subfamily B member 8 (DNAJB8) is a protein
from Homo sapiens identified by UniProt accession
Q8NHS0, 232 residues long.
MolForge cross-references it against 0 known binders and
62 disease associations.
Target properties
| Protein name | DnaJ homolog subfamily B member 8 |
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| UniProt accession | Q8NHS0 |
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| Gene | DNAJB8 |
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| Organism | Homo sapiens |
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| Length | 232 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (62)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- eosinophil count · score 0.34
- mathematical ability · score 0.30
- mean corpuscular volume · score 0.27
- leukocyte count · score 0.27
- body height · score 0.26
- basophil percentage of granulocytes · score 0.26
- basophil percentage of leukocytes · score 0.24
- mean corpuscular hemoglobin concentration · score 0.18
- body mass index · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NHS0-F1 | alphafold | PREDICTED | 64.87 | — |
Amino-acid sequence (232 residues)
MANYYEVLGV QASASPEDIK KAYRKLALRW HPDKNPDNKE EAEKKFKLVS EAYEVLSDSK KRSLYDRAGC DSWRAGGGAS TPYHSPFDTG YTFRNPEDIF REFFGGLDPF SFEFWDSPFN SDRGGRGHGL RGAFSAGFGE FPAFMEAFSS FNMLGCSGGS HTTFSSTSFG GSSSGSSGFK SVMSSTEMIN GHKVTTKRIV ENGQERVEVE EDGQLKSVTV NGKEQLKWMD SK
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