About Modulator of smoothened protein
Modulator of smoothened protein (MOSMO) is a protein
from Homo sapiens identified by UniProt accession
Q8NHV5, 167 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Modulator of smoothened protein |
|---|
| UniProt accession | Q8NHV5 |
|---|
| Gene | MOSMO |
|---|
| Organism | Homo sapiens |
|---|
| Length | 167 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (68)
Diseases linked to this target (Open Targets).
- Heterotaxia · score 0.07
- visceral heterotaxy · score 0.05
- heterotaxy, visceral, 12, autosomal · score 0.05
- scimitar syndrome · score 0.05
- congenital absence of upper arm and forearm with hand present · score 0.05
- heterotaxy, visceral, 9, autosomal, with male infertility · score 0.04
- congenital heart disease · score 0.04
- right atrial isomerism · score 0.04
- pentalogy of Cantrell · score 0.04
- Bardet-Biedl syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NHV5-F1 | alphafold | PREDICTED | 88.68 | — |
Amino-acid sequence (167 residues)
MDKLTIISGC LFLAADIFAI ASIANPDWIN TGESAGALTV GLVRQCQTIH GRDRTCIPPR LPPEWVTTLF FIIMGIISLT VTCGLLVASH WRREATKYAR WIAFTGMILF CMAALIFPIG FYINEVGGQP YKLPNNTVVG SSYVLFVLSI FFTIVGLLFA GKVCLPG
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