Otospiralin (OTOS)

About Otospiralin

Otospiralin (OTOS) is a protein from Homo sapiens identified by UniProt accession Q8NHW6, 89 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	Otospiralin
UniProt accession	Q8NHW6
Gene	OTOS
Organism	Homo sapiens
Length	89 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

protein measurement · score 0.22
neuroticism measurement · score 0.11
deafness · score 0.07
gut microbiome measurement · score 0.06
otosclerosis · score 0.06
hearing loss, autosomal dominant 75 · score 0.05
hearing loss, autosomal dominant 77 · score 0.05
Non-syndromic genetic deafness · score 0.05
hearing loss, autosomal dominant 80 · score 0.05
X-linked mixed deafness with perilymphatic gusher · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NHW6-F1	alphafold	PREDICTED	81.25	—

Amino-acid sequence (89 residues)

MQACMVPGLA LCLLLGPLAG AKPVQEEGDP YAELPAMPYW PFSTSDFWNY VQHFQALGAY PQIEDMARTF FAHFPLGSTL GFHVPYQED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards