About Methyl-CpG-binding domain protein 3-like 2
Methyl-CpG-binding domain protein 3-like 2 (MBD3L2) is a protein
from Homo sapiens identified by UniProt accession
Q8NHZ7, 208 residues long.
MolForge cross-references it against 0 known binders and
11 disease associations.
Target properties
| Protein name | Methyl-CpG-binding domain protein 3-like 2 |
|---|
| UniProt accession | Q8NHZ7 |
|---|
| Gene | MBD3L2 |
|---|
| Organism | Homo sapiens |
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| Length | 208 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (11)
Diseases linked to this target (Open Targets).
- refractive error measurement · score 0.10
- body height · score 0.02
- Red cell distribution width · score 0.02
- birth weight · score 0.02
- polycystic ovary syndrome · score 0.02
- Facioscapulohumeral dystrophy · score 0.01
- facioscapulohumeral muscular dystrophy · score 0.01
- cancer · score 0.00
- pancreatic neoplasm · score 0.00
- mucous membrane pemphigoid · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NHZ7-F1 | alphafold | PREDICTED | 65.58 | — |
Amino-acid sequence (208 residues)
MGEPAFTSFP SLPVLGKLKR NMMPWALQKK REIHMAKAHR RRAARSALPM RLTSCIFRRP VTRIRSHPDN QVRRRKGDEH LEKPQQLCAY RRLQALQPCS SQGEGSSPLH LESVLSILAP GTAGESLDRA GAERVRSPLE PTPGRFPAVA GGPTPGMGCQ LPPPLSGQLV TPADIRRQAR RVKKARERLA KALQADRLAR RAEMLTGG
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