About Angiopoietin-related protein 6
Angiopoietin-related protein 6 (ANGPTL6) is a protein
from Homo sapiens identified by UniProt accession
Q8NI99, 470 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | Angiopoietin-related protein 6 |
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| UniProt accession | Q8NI99 |
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| Gene | ANGPTL6 |
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| Organism | Homo sapiens |
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| Length | 470 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (105)
Diseases linked to this target (Open Targets).
- brain aneurysm · score 0.37
- Familial cerebral saccular aneurysm · score 0.37
- neurodegenerative disease · score 0.27
- serum gamma-glutamyl transferase measurement · score 0.26
- Genetic visceral malformation of the liver, biliary tract, pancreas or spleen · score 0.25
- hepatocellular carcinoma · score 0.10
- psoriasis · score 0.07
- Obesity · score 0.06
- type 2 diabetes mellitus · score 0.05
- obesity due to melanocortin 4 receptor deficiency · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NI99-F1 | alphafold | PREDICTED | 74.77 | — |
Amino-acid sequence (470 residues)
MGKPWLRALQ LLLLLGASWA RAGAPRCTYT FVLPPQKFTG AVCWSGPAST RATPEAANAS ELAALRMRVG RHEELLRELQ RLAAADGAVA GEVRALRKES RGLSARLGQL RAQLQHEAGP GAGPGADLGA EPAAALALLG ERVLNASAEA QRAAARFHQL DVKFRELAQL VTQQSSLIAR LERLCPGGAG GQQQVLPPPP LVPVVPVRLV GSTSDTSRML DPAPEPQRDQ TQRQQEPMAS PMPAGHPAVP TKPVGPWQDC AEARQAGHEQ SGVYELRVGR HVVSVWCEQQ LEGGGWTVIQ RRQDGSVNFF TTWQHYKAGF GRPDGEYWLG LEPVYQLTSR GDHELLVLLE DWGGRGARAH YDGFSLEPES DHYRLRLGQY HGDAGDSLSW HNDKPFSTVD RDRDSYSGNC ALYQRGGWWY HACAHSNLNG VWHHGGHYRS RYQDGVYWAE FRGGAYSLRK AAMLIRPLKL
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