Homeobox protein Nkx-2.3 (NKX2-3)

About Homeobox protein Nkx-2.3

Homeobox protein Nkx-2.3 (NKX2-3) is a protein from Homo sapiens identified by UniProt accession Q8TAU0, 364 residues long. MolForge cross-references it against 0 known binders and 290 disease associations.

Target properties

Protein name	Homeobox protein Nkx-2.3
UniProt accession	Q8TAU0
Gene	NKX2-3
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (290)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.47
ulcerative colitis · score 0.46
inflammatory bowel disease · score 0.46
hypothyroidism · score 0.45
Crohn's disease · score 0.43
platelet count · score 0.42
ankylosing spondylitis · score 0.40
neurodegenerative disease · score 0.39
erythrocyte count · score 0.38
leukocyte count · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TAU0-F1	alphafold	PREDICTED	59.00	—

Amino-acid sequence (364 residues)

MMLPSPVTST PFSVKDILNL EQQHQHFHGA HLQADLEHHF HSAPCMLAAA EGTQFSDGGE EDEEDEGEKL SYLNSLAAAD GHGDSGLCPQ GYVHTVLRDS CSEPKEHEEE PEVVRDRSQK SCQLKKSLET AGDCKAAEES ERPKPRSRRK PRVLFSQAQV FELERRFKQQ RYLSAPEREH LASSLKLTST QVKIWFQNRR YKCKRQRQDK SLELGAHAPP PPPRRVAVPV LVRDGKPCVT PSAQAYGAPY SVGASAYSYN SFPAYGYGNS AAAAAAAAAA AAAAAAYSSS YGCAYPAGGG GGGGGTSAAT TAMQPACSAA GGGPFVNVSN LGGFGSGGSA QPLHQGTAAG AACAQGTLQG IRAW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards