About Solute carrier family 7 member 14
Solute carrier family 7 member 14 (SLC7A14) is a protein
from Homo sapiens identified by UniProt accession
Q8TBB6, 771 residues long.
MolForge cross-references it against 0 known binders and
79 disease associations.
Target properties
| Protein name | Solute carrier family 7 member 14 |
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| UniProt accession | Q8TBB6 |
|---|
| Gene | SLC7A14 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 771 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (79)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.58
- Retinal dystrophy · score 0.38
- Alzheimer disease · score 0.31
- Parkinson disease · score 0.31
- neurodegenerative disease · score 0.31
- lysosomal storage disease · score 0.31
- multiple sclerosis · score 0.31
- oleic acid measurement · score 0.27
- CCL2 measurement · score 0.27
- fatty acid measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TBB6-F1 | alphafold | PREDICTED | 72.69 | — |
Amino-acid sequence (771 residues)
MSGFFTSLDP RRVQWGAAWY AMHSRILRTK PVESMLEGTG TTTAHGTKLA QVLTTVDLIS LGVGSCVGTG MYVVSGLVAK EMAGPGVIVS FIIAAVASIL SGVCYAEFGV RVPKTTGSAY TYSYVTVGEF VAFFIGWNLI LEYLIGTAAG ASALSSMFDS LANHTISRWM ADSVGTLNGL GKGEESYPDL LALLIAVIVT IIVALGVKNS IGFNNVLNVL NLAVWVFIMI AGLFFINGKY WAEGQFLPHG WSGVLQGAAT CFYAFIGFDI IATTGEEAKN PNTSIPYAIT ASLVICLTAY VSVSVILTLM VPYYTIDTES PLMEMFVAHG FYAAKFVVAI GSVAGLTVSL LGSLFPMPRV IYAMAGDGLL FRFLAHVSSY TETPVVACIV SGFLAALLAL LVSLRDLIEM MSIGTLLAYT LVSVCVLLLR YQPESDIDGF VKFLSEEHTK KKEGILADCE KEACSPVSEG DEFSGPATNT CGAKNLPSLG DNEMLIGKSD KSTYNVNHPN YGTVDMTTGI EADESENIYL IKLKKLIGPH YYTMRIRLGL PGKMDRPTAA TGHTVTICVL LLFILMFIFC SFIIFGSDYI SEQSWWAILL VVLMVLLIST LVFVILQQPE NPKKLPYMAP CLPFVPAFAM LVNIYLMLKL STITWIRFAV WCFVGLLIYF GYGIWNSTLE ISAREEALHQ STYQRYDVDD PFSVEEGFSY ATEGESQEDW GGPTEDKGFY YQQMSDAKAN GRTSSKAKSK SKHKQNSEAL IANDELDYSP E
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