About Transmembrane protein 254
Transmembrane protein 254 (TMEM254) is a protein
from Homo sapiens identified by UniProt accession
Q8TBM7, 123 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Transmembrane protein 254 |
|---|
| UniProt accession | Q8TBM7 |
|---|
| Gene | TMEM254 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 123 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (22)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- blood protein measurement · score 0.21
- drug use measurement · score 0.06
- hypoparathyroidism, familial isolated, 2 · score 0.06
- Primary hypomagnesemia with secondary hypocalcemia · score 0.06
- pseudohypoparathyroidism type 2 · score 0.05
- 22q11.2 deletion syndrome · score 0.05
- Familial isolated hypoparathyroidism · score 0.04
- hyperparathyroidism · score 0.04
- familial isolated hyperparathyroidism · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TBM7-F1 | alphafold | PREDICTED | 89.76 | — |
Amino-acid sequence (123 residues)
MATAAGATYF QRGSLFWFTV ITLSFGYYTW VVFWPQSIPY QNLGPLGPFT QYLVDHHHTL LCNGYWLAWL IHVGESLYAI VLCKHKGITS GRAQLLWFLQ TFFFGIASLT ILIAYKRKRQ KQT
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