About Melanocortin-2 receptor accessory protein
Melanocortin-2 receptor accessory protein (MRAP) is a protein
from Homo sapiens identified by UniProt accession
Q8TCY5, 172 residues long.
MolForge cross-references it against 0 known binders and
138 disease associations.
Target properties
| Protein name | Melanocortin-2 receptor accessory protein |
|---|
| UniProt accession | Q8TCY5 |
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| Gene | MRAP |
|---|
| Organism | Homo sapiens |
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| Length | 172 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (138)
Diseases linked to this target (Open Targets).
- familial glucocorticoid deficiency · score 0.69
- hypertension · score 0.39
- alternating hemiplegia of childhood · score 0.37
- X-linked adrenal hypoplasia congenita · score 0.37
- blood pressure · score 0.31
- biliary tract cancer · score 0.23
- testosterone measurement · score 0.20
- genetic disorder · score 0.19
- motor neuron disease · score 0.04
- spondylitis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TCY5-F1 | alphafold | PREDICTED | 58.09 | — |
Amino-acid sequence (172 residues)
MANGTNASAP YYSYEYYLDY LDLIPVDEKK LKAHKHSIVI AFWVSLAAFV VLLFLILLYM SWSASPQMRN SPKHHQTCPW SHGLNLHLCI QKCLPCHREP LATSQAQASS VEPGSRTGPD QPLRQESSST LPLGGFQTHP TLLWELTLNG GPLVRSKPSE PPPGDRTSQL QS
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