About Solute carrier family 2, facilitated glucose transporter member 12
Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12) is a protein
from Homo sapiens identified by UniProt accession
Q8TD20, 617 residues long.
MolForge cross-references it against 0 known binders and
103 disease associations.
Target properties
| Protein name | Solute carrier family 2, facilitated glucose transporter member 12 |
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| UniProt accession | Q8TD20 |
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| Gene | SLC2A12 |
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| Organism | Homo sapiens |
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| Length | 617 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (103)
Diseases linked to this target (Open Targets).
- IGF-1 measurement · score 0.34
- forced expiratory volume · score 0.32
- coronary artery disease · score 0.30
- metabolite measurement · score 0.15
- C-reactive protein measurement · score 0.12
- gonorrhea · score 0.07
- mean corpuscular hemoglobin · score 0.06
- peak expiratory flow · score 0.06
- myocardial infarction · score 0.06
- calcium measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8TD20-F1 | alphafold | PREDICTED | 74.88 | — |
Amino-acid sequence (617 residues)
MVPVENTEGP SLLNQKGTAV ETEGSGSRHP PWARGCGMFT FLSSVTAAVS GLLVGYELGI ISGALLQIKT LLALSCHEQE MVVSSLVIGA LLASLTGGVL IDRYGRRTAI ILSSCLLGLG SLVLILSLSY TVLIVGRIAI GVSISLSSIA TCVYIAEIAP QHRRGLLVSL NELMIVIGIL SAYISNYAFA NVFHGWKYMF GLVIPLGVLQ AIAMYFLPPS PRFLVMKGQE GAASKVLGRL RALSDTTEEL TVIKSSLKDE YQYSFWDLFR SKDNMRTRIM IGLTLVFFVQ ITGQPNILFY ASTVLKSVGF QSNEAASLAS TGVGVVKVIS TIPATLLVDH VGSKTFLCIG SSVMAASLVT MGIVNLNIHM NFTHICRSHN SINQSLDESV IYGPGNLSTN NNTLRDHFKG ISSHSRSSLM PLRNDVDKRG ETTSASLLNA GLSHTEYQIV TDPGDVPAFL KWLSLASLLV YVAAFSIGLG PMPWLVLSEI FPGGIRGRAM ALTSSMNWGI NLLISLTFLT VTDLIGLPWV CFIYTIMSLA SLLFVVMFIP ETKGCSLEQI SMELAKVNYV KNNICFMSHH QEELVPKQPQ KRKPQEQLLE CNKLCGRGQS RQLSPET
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