G-protein coupled receptor 151 (GPR151)

About G-protein coupled receptor 151

G-protein coupled receptor 151 (GPR151) is a protein from Homo sapiens identified by UniProt accession Q8TDV0, 419 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.

Target properties

Protein name	G-protein coupled receptor 151
UniProt accession	Q8TDV0
Gene	GPR151
Organism	Homo sapiens
Length	419 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (53)

Diseases linked to this target (Open Targets).

body fat percentage · score 0.47
fat body mass · score 0.41
waist circumference · score 0.35
body mass index · score 0.33
self reported educational attainment · score 0.26
essential tremor · score 0.26
waist-hip ratio · score 0.15
body weight · score 0.12
body weights and measures · score 0.09
hypertension · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TDV0-F1	alphafold	PREDICTED	78.07	—

Amino-acid sequence (419 residues)

MLAAAFADSN SSSMNVSFAH LHFAGGYLPS DSQDWRTIIP ALLVAVCLVG FVGNLCVIGI LLHNAWKGKP SMIHSLILNL SLADLSLLLF SAPIRATAYS KSVWDLGWFV CKSSDWFIHT CMAAKSLTIV VVAKVCFMYA SDPAKQVSIH NYTIWSVLVA IWTVASLLPL PEWFFSTIRH HEGVEMCLVD VPAVAEEFMS MFGKLYPLLA FGLPLFFASF YFWRAYDQCK KRGTKTQNLR NQIRSKQVTV MLLSIAIISA LLWLPEWVAW LWVWHLKAAG PAPPQGFIAL SQVLMFSISS ANPLIFLVMS EEFREGLKGV WKWMITKKPP TVSESQETPA GNSEGLPDKV PSPESPASIP EKEKPSSPSS GKGKTEKAEI PILPDVEQFW HERDTVPSVQ DNDPIPWEHE DQETGEGVK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards