Netrin-5 (NTN5)

About Netrin-5

Netrin-5 (NTN5) is a protein from Homo sapiens identified by UniProt accession Q8WTR8, 489 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.

Target properties

Protein name	Netrin-5
UniProt accession	Q8WTR8
Gene	NTN5
Organism	Homo sapiens
Length	489 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (115)

Diseases linked to this target (Open Targets).

alkaline phosphatase measurement · score 0.27
Diarrhea · score 0.20
body height · score 0.09
anti-polyomavirus 2 antibody measurement · score 0.07
age at menarche · score 0.07
alcohol use disorder measurement · score 0.06
triglyceride measurement · score 0.06
mean corpuscular hemoglobin concentration · score 0.05
hemoglobin measurement · score 0.05
neutrophil count · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WTR8-F1	alphafold	PREDICTED	83.59	—

Amino-acid sequence (489 residues)

MPVTFALLLL LGQATADPCY DPQGRPQFCL PPVTQLAAVA ASCPQACALS PGNHLGARET CNGSLTLALG GPFLLTSVSL RFCTPGPPAL ILSAAWASGG PWRLLWHRPA WPGALGGPER VTFHSTPGPK ATVAASHLRV EFGGQAGLAA AGLRGRCQCH GHAARCAARA RPPRCHCRHH TTGPGCESCR PSHRDWPWRP ATPRHPHPCL PCSCNQHARR CRFNSELFRL SGGRSGGVCE RCRHHTAGRH CHYCQPGFWR DPSQPIFSRR ACRACQCHPI GATGGTCNQT SGQCTCKLGV TGLTCNRCGP GYQQSRSPRM PCQRIPEATT TLATTPGAYS SDPQCQNYCN MSDTRVHMSL RRYCQQDHVL RAQVLASEAA GPAWQRLAVR VLAVYKQRAQ PVRRGDQDAW VPRADLTCGC LRLQPGTDYL LLGSAVGDPD PTRLILDRHG LALPWRPRWA RPLKRLQQEE RAGGCRGVRA PTPSPRPEH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards