Histone-lysine N-methyltransferase SETD7 (SETD7)

About Histone-lysine N-methyltransferase SETD7

Histone-lysine N-methyltransferase SETD7 (SETD7) is a protein from Homo sapiens identified by UniProt accession Q8WTS6, 366 residues long. MolForge cross-references it against 0 known binders and 145 disease associations.

Target properties

Protein name	Histone-lysine N-methyltransferase SETD7
UniProt accession	Q8WTS6
Gene	SETD7
Organism	Homo sapiens
Length	366 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (145)

Diseases linked to this target (Open Targets).

lycopene measurement · score 0.29
breast adenocarcinoma · score 0.24
neoplasm · score 0.11
hepatocellular carcinoma · score 0.10
cancer · score 0.10
breast cancer · score 0.09
acute myeloid leukemia · score 0.08
papillary thyroid carcinoma · score 0.08
nonpapillary renal cell carcinoma · score 0.07
lung adenocarcinoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WTS6-F1	alphafold	PREDICTED	94.42	—

Amino-acid sequence (366 residues)

MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGNSV YHFDKSTSSC ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP EWYQVELKAF QATQQK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards