Protein DDI1 homolog 1 (DDI1)

About Protein DDI1 homolog 1

Protein DDI1 homolog 1 (DDI1) is a protein from Homo sapiens identified by UniProt accession Q8WTU0, 396 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.

Target properties

Protein name	Protein DDI1 homolog 1
UniProt accession	Q8WTU0
Gene	DDI1
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (60)

Diseases linked to this target (Open Targets).

angina pectoris · score 0.22
coronary artery disease · score 0.21
high density lipoprotein cholesterol measurement · score 0.19
myocardial infarction · score 0.18
pulse pressure measurement · score 0.17
Vasodilators used in cardiac diseases use measurement · score 0.16
low density lipoprotein cholesterol measurement · score 0.16
carotid artery intima media thickness · score 0.16
PHF-tau measurement · score 0.13
adrenal suppression measurement · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WTU0-F1	alphafold	PREDICTED	77.53	—

Amino-acid sequence (396 residues)

MLITVYCVRR DLSEVTFSLQ VSPDFELRNF KVLCEAESRV PVEEIQIIHM ERLLIEDHCS LGSYGLKDGD IVVLLQKDNV GPRAPGRAPN QPRVDFSGIA VPGTSSSRPQ HPGQQQQRTP AAQRSQGLAS GEKVAGLQGL GSPALIRSML LSNPHDLSLL KERNPPLAEA LLSGSLETFS QVLMEQQREK ALREQERLRL YTADPLDREA QAKIEEEIRQ QNIEENMNIA IEEAPESFGQ VTMLYINCKV NGHPLKAFVD SGAQMTIMSQ ACAERCNIMR LVDRRWAGVA KGVGTQRIIG RVHLAQIQIE GDFLQCSFSI LEDQPMDMLL GLDMLRRHQC SIDLKKNVLV IGTTGTQTYF LPEGELPLCS RMVSGQDESS DKEITHSVMD SGRKEH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards