Protein FAM222B (FAM222B)

About Protein FAM222B

Protein FAM222B (FAM222B) is a protein from Homo sapiens identified by UniProt accession Q8WU58, 562 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Protein FAM222B
UniProt accession	Q8WU58
Gene	FAM222B
Organism	Homo sapiens
Length	562 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin concentration · score 0.34
mean corpuscular hemoglobin · score 0.34
mean corpuscular volume · score 0.33
erythrocyte count · score 0.31
Red cell distribution width · score 0.29
HbA1c measurement · score 0.28
red blood cell density measurement · score 0.27
hemoglobin measurement · score 0.27
bilirubin measurement · score 0.26
reticulocyte count · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WU58-F1	alphafold	PREDICTED	47.82	—

Amino-acid sequence (562 residues)

MLACLPGPGD LSFQLLSHTQ MNTGLQKWDT TQKMRTAHYP TPAELDAYAK KVANNPLTIK IFPNSVKVPQ RKHVRRTVNG LDTSAQRYSP YPTQAATKAG LLAIVKVPAK SILKDFDGTR ARLLPEAIMN PPVAPYATVA PSTLAHPQAQ ALARQQALQH AQTLAHAPPQ TLQHPQGIPP PQALSHPQSL QQPQGLGHPQ PMAQTQGLVH PQALAHQGLQ HPHNPLLHGG RKMPDSDAPP NVTVSTSTIP LSMAATLQHS QPPDLSSIVH QINQFCQTRA GISTTSVCEG QIANPSPISR SLLINASTRV STHSVPTPMP SCVVNPMEHT HAATAALPAA GPVNLPTGIS RVPTGYPSDL KPVTWNQHQL AHLQQMCSEA SGTPAPGLTG KHAAGRELAG PGFVGKAPAY PQELCLAQSF HLKPPLEKPT PSPPVNGMAA PLAYPNGHYF QPLWNNILPT PNSDSSGSQD LAMPFHGGQP TGAPLDCAAA PGAHYRAGTG GGPVASQNSL MQTVDYLSGD FQQACFREQS LAMLSKAHRA PGNRAPDPTE SRSLHIQHPG YR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards