Phospholipase ABHD3 (ABHD3)

About Phospholipase ABHD3

Phospholipase ABHD3 (ABHD3) is a protein from Homo sapiens identified by UniProt accession Q8WU67, 409 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

Target properties

Protein name	Phospholipase ABHD3
UniProt accession	Q8WU67
Gene	ABHD3
Organism	Homo sapiens
Length	409 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.33
creatinine measurement · score 0.23
phosphatidylcholine measurement · score 0.19
glioblastoma multiforme · score 0.18
phospholipid measurement · score 0.10
cortical surface area measurement · score 0.05
neuroimaging measurement · score 0.04
mean corpuscular volume · score 0.04
brain measurement · score 0.04
appendicular lean mass · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WU67-F1	alphafold	PREDICTED	93.36	—

Amino-acid sequence (409 residues)

MQRLAMDLRM LSRELSLYLE HQVRVGFFGS GVGLSLILGF SVAYAFYYLS SIAKKPQLVT GGESFSRFLQ DHCPVVTETY YPTVWCWEGR GQTLLRPFIT SKPPVQYRNE LIKTADGGQI SLDWFDNDNS TCYMDASTRP TILLLPGLTG TSKESYILHM IHLSEELGYR CVVFNNRGVA GENLLTPRTY CCANTEDLET VIHHVHSLYP SAPFLAAGVS MGGMLLLNYL GKIGSKTPLM AAATFSVGWN TFACSESLEK PLNWLLFNYY LTTCLQSSVN KHRHMFVKQV DMDHVMKAKS IREFDKRFTS VMFGYQTIDD YYTDASPSPR LKSVGIPVLC LNSVDDVFSP SHAIPIETAK QNPNVALVLT SYGGHIGFLE GIWPRQSTYM DRVFKQFVQA MVEHGHELS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards