About Transmembrane protein 174
Transmembrane protein 174 (TMEM174) is a protein
from Homo sapiens identified by UniProt accession
Q8WUU8, 243 residues long.
MolForge cross-references it against 0 known binders and
112 disease associations.
Target properties
| Protein name | Transmembrane protein 174 |
|---|
| UniProt accession | Q8WUU8 |
|---|
| Gene | TMEM174 |
|---|
| Organism | Homo sapiens |
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| Length | 243 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (112)
Diseases linked to this target (Open Targets).
- Crohn's disease · score 0.34
- mean platelet volume · score 0.31
- delivery measurement · score 0.29
- heel bone mineral density · score 0.27
- facial hair thickness measurement · score 0.26
- blood urea nitrogen measurement · score 0.25
- sclerosing cholangitis · score 0.24
- ulcerative colitis · score 0.24
- ankylosing spondylitis · score 0.24
- psoriasis · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WUU8-F1 | alphafold | PREDICTED | 58.49 | — |
Amino-acid sequence (243 residues)
MEQGSGRLED FPVNVFSVTP YTPSTADIQV SDDDKAGATL LFSGIFLGLV GITFTVMGWI KYQGVSHFEW TQLLGPVLLS VGVTFILIAV CKFKMLSCQL CKESEERVPD SEQTPGGPSF VFTGINQPIT FHGATVVQYI PPPYGSPEPM GINTSYLQSV VSPCGLITSG GAAAAMSSPP QYYTIYPQDN SAFVVDEGCL SFTDGGNHRP NPDVDQLEET QLEEEACACF SPPPYEEIYS LPR
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