Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8)

About Mitochondrial coenzyme A diphosphatase NUDT8

Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) is a protein from Homo sapiens identified by UniProt accession Q8WV74, 236 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	Mitochondrial coenzyme A diphosphatase NUDT8
UniProt accession	Q8WV74
Gene	NUDT8
Organism	Homo sapiens
Length	236 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.32
urate measurement · score 0.21
waist-hip ratio · score 0.11
BMI-adjusted waist-hip ratio · score 0.10
urinary metabolite measurement · score 0.10
apolipoprotein A 1 measurement · score 0.08
BMI-adjusted waist circumference · score 0.03
mean platelet volume · score 0.03
body height · score 0.03
prostate carcinoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WV74-F1	alphafold	PREDICTED	83.94	—

Amino-acid sequence (236 residues)

MLPDCLSAEG ELRCRRLLAG ATARLRARPA SAAVLVPLCS VRGVPALLYT LRSSRLTGRH KGDVSFPGGK CDPADQDVVH TALRETREEL GLAVPEEHVW GLLRPVYDPQ KATVVPVLAG VGPLDPQSLR PNSEEVDEVF ALPLAHLLQT QNQGYTHFCR GGHFRYTLPV FLHGPHRVWG LTAVITEFAL QLLAPGTYQP RLAGLTCSGA EGLARPKQPL ASPCQASSTP GLNKGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards