About BTB/POZ domain-containing protein KCTD4
BTB/POZ domain-containing protein KCTD4 (KCTD4) is a protein
from Homo sapiens identified by UniProt accession
Q8WVF5, 259 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | BTB/POZ domain-containing protein KCTD4 |
|---|
| UniProt accession | Q8WVF5 |
|---|
| Gene | KCTD4 |
|---|
| Organism | Homo sapiens |
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| Length | 259 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (24)
Diseases linked to this target (Open Targets).
- cancer · score 0.07
- esophageal squamous cell carcinoma · score 0.07
- glioblastoma multiforme · score 0.03
- neoplasm · score 0.02
- Red cell distribution width · score 0.02
- cystic fibrosis · score 0.02
- colorectal adenocarcinoma · score 0.02
- medulloblastoma · score 0.02
- astrocytoma · score 0.01
- oligodendroglioma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WVF5-F1 | alphafold | PREDICTED | 81.67 | — |
Amino-acid sequence (259 residues)
MERKINRREK EKEYEGKHNS LEDTDQGKNC KSTLMTLNVG GYLYITQKQT LTKYPDTFLE GIVNGKILCP FDADGHYFID RDGLLFRHVL NFLRNGELLL PEGFRENQLL AQEAEFFQLK GLAEEVKSRW EKEQLTPRET TFLEITDNHD RSQGLRIFCN APDFISKIKS RIVLVSKSRL DGFPEEFSIS SNIIQFKYFI KSENGTRLVL KEDNTFVCTL ETLKFEAIMM ALKCGFRLLT SLDCSKGSIV HSDALHFIK
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