About Inactive heparanase-2
Inactive heparanase-2 (HPSE2) is a protein
from Homo sapiens identified by UniProt accession
Q8WWQ2, 592 residues long.
MolForge cross-references it against 0 known binders and
194 disease associations.
Target properties
| Protein name | Inactive heparanase-2 |
|---|
| UniProt accession | Q8WWQ2 |
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| Gene | HPSE2 |
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| Organism | Homo sapiens |
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| Length | 592 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (194)
Diseases linked to this target (Open Targets).
- Ochoa syndrome · score 0.74
- congenital anomaly of kidney and urinary tract · score 0.42
- congenital hydronephrosis · score 0.42
- aspartate aminotransferase measurement · score 0.31
- migraine disorder · score 0.29
- childhood onset asthma · score 0.22
- Headache · score 0.21
- systolic blood pressure · score 0.20
- diastolic blood pressure · score 0.20
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WWQ2-F1 | alphafold | PREDICTED | 82.34 | — |
Amino-acid sequence (592 residues)
MRVLCAFPEA MPSSNSRPPA CLAPGALYLA LLLHLSLSSQ AGDRRPLPVD RAAGLKEKTL ILLDVSTKNP VRTVNENFLS LQLDPSIIHD GWLDFLSSKR LVTLARGLSP AFLRFGGKRT DFLQFQNLRN PAKSRGGPGP DYYLKNYEDD IVRSDVALDK QKGCKIAQHP DVMLELQREK AAQMHLVLLK EQFSNTYSNL ILTARSLDKL YNFADCSGLH LIFALNALRR NPNNSWNSSS ALSLLKYSAS KKYNISWELG NEPNNYRTMH GRAVNGSQLG KDYIQLKSLL QPIRIYSRAS LYGPNIGRPR KNVIALLDGF MKVAGSTVDA VTWQHCYIDG RVVKVMDFLK TRLLDTLSDQ IRKIQKVVNT YTPGKKIWLE GVVTTSAGGT NNLSDSYAAG FLWLNTLGML ANQGIDVVIR HSFFDHGYNH LVDQNFNPLP DYWLSLLYKR LIGPKVLAVH VAGLQRKPRP GRVIRDKLRI YAHCTNHHNH NYVRGSITLF IINLHRSRKK IKLAGTLRDK LVHQYLLQPY GQEGLKSKSV QLNGQPLVMV DDGTLPELKP RPLRAGRTLV IPPVTMGFYV VKNVNALACR YR
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