Ectodysplasin-A receptor-associated adapter protein…

About Ectodysplasin-A receptor-associated adapter protein

Ectodysplasin-A receptor-associated adapter protein (EDARADD) is a protein from Homo sapiens identified by UniProt accession Q8WWZ3, 215 residues long. MolForge cross-references it against 0 known binders and 254 disease associations.

Target properties

Protein name	Ectodysplasin-A receptor-associated adapter protein
UniProt accession	Q8WWZ3
Gene	EDARADD
Organism	Homo sapiens
Length	215 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (254)

Diseases linked to this target (Open Targets).

autosomal recessive hypohidrotic ectodermal dysplasia · score 0.72
hypohidrotic ectodermal dysplasia · score 0.67
tooth agenesis · score 0.44
neurodegenerative disease · score 0.39
autosomal dominant hypohidrotic ectodermal dysplasia · score 0.38
hypothyroidism · score 0.35
total blood protein measurement · score 0.30
insomnia · score 0.30
myxedema · score 0.26
thyroid disease · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WWZ3-F1	alphafold	PREDICTED	72.81	—

Amino-acid sequence (215 residues)

MGLRTTKQMG RGTKAPGHQE DHMVKEPVED TDPSTLSFNM SDKYPIQDTE LPKAEECDTI TLNCPRNSDM KNQGEENGFP DSTGDPLPEI SKDNSCKENC TCSSCLLRAP TISDLLNDQD LLDVIRIKLD PCHPTVKNWR NFASKWGMSY DELCFLEQRP QSPTLEFLLR NSQRTVGQLM ELCRLYHRAD VEKVLRRWVD EEWPKRERGD PSRHF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Ectodysplasin-A receptor-associated adapter protein (EDARADD)