About Negative elongation factor B
Negative elongation factor B (NELFB) is a protein
from Homo sapiens identified by UniProt accession
Q8WX92, 580 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Negative elongation factor B |
|---|
| UniProt accession | Q8WX92 |
|---|
| Gene | NELFB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 580 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.59
- neurodegenerative disease · score 0.48
- head and neck squamous cell carcinoma · score 0.18
- squamous cell lung carcinoma · score 0.18
- endometrial cancer · score 0.18
- lung adenocarcinoma · score 0.18
- gastric adenocarcinoma · score 0.17
- esophageal cancer · score 0.16
- prostate adenocarcinoma · score 0.11
- ulcerative colitis · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WX92-F1 | alphafold | PREDICTED | 89.21 | — |
Amino-acid sequence (580 residues)
MFAGLQDLGV ANGEDLKETL TNCTEPLKAI EQFQTENGVL LPSLQSALPF LDLHGTPRLE FHQSVFDELR DKLLERVSAI ASEGKAEERY KKLEDLLEKS FSLVKMPSLQ PVVMCVMKHL PKVPEKKLKL VMADKELYRA CAVEVKRQIW QDNQALFGDE VSPLLKQYIL EKESALFSTE LSVLHNFFSP SPKTRRQGEV VQRLTRMVGK NVKLYDMVLQ FLRTLFLRTR NVHYCTLRAE LLMSLHDLDV GEICTVDPCH KFTWCLDACI RERFVDSKRA RELQGFLDGV KKGQEQVLGD LSMILCDPFA INTLALSTVR HLQELVGQET LPRDSPDLLL LLRLLALGQG AWDMIDSQVF KEPKMEVELI TRFLPMLMSF LVDDYTFNVD QKLPAEEKAP VSYPNTLPES FTKFLQEQRM ACEVGLYYVL HITKQRNKNA LLRLLPGLVE TFGDLAFGDI FLHLLTGNLA LLADEFALED FCSSLFDGFF LTASPRKENV HRHALRLLIH LHPRVAPSKL EALQKALEPT GQSGEAVKEL YSQLGEKLEQ LDHRKPSPAQ AAETPALELP LPSVPAPAPL
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