Radial spoke head 1 homolog (RSPH1)

About Radial spoke head 1 homolog

Radial spoke head 1 homolog (RSPH1) is a protein from Homo sapiens identified by UniProt accession Q8WYR4, 309 residues long. MolForge cross-references it against 0 known binders and 122 disease associations.

Target properties

Protein name	Radial spoke head 1 homolog
UniProt accession	Q8WYR4
Gene	RSPH1
Organism	Homo sapiens
Length	309 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (122)

Diseases linked to this target (Open Targets).

primary ciliary dyskinesia · score 0.70
erythrocyte count · score 0.28
red blood cell density measurement · score 0.24
neurodegenerative disease · score 0.23
genetic disorder · score 0.19
self reported educational attainment · score 0.14
azoospermia · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.08
partial chromosome Y deletion · score 0.07
congenital bilateral absence of vas deferens · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WYR4-F1	alphafold	PREDICTED	74.19	—

Amino-acid sequence (309 residues)

MSDLGSEELE EEGENDIGEY EGGRNEAGER HGRGRARLPN GDTYEGSYEF GKRHGQGIYK FKNGARYIGE YVRNKKHGQG TFIYPDGSRY EGEWANDLRH GHGVYYYINN DTYTGEWFAH QRHGQGTYLY AETGSKYVGT WVNGQQEGTA ELIHLNHRYQ GKFLNKNPVG PGKYVFDVGC EQHGEYRLTD MERGEEEEEE ELVTVVPKWK ATQITELALW TPTLPKKPTS TDGPGQDAPG AESAGEPGEE AQALLEGFEG EMDMRPGDED ADVLREESRE YDQEEFRYDM DEGNINSEEE ETRQSDLQD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards