About Kelch-like protein 6
Kelch-like protein 6 (KLHL6) is a protein
from Homo sapiens identified by UniProt accession
Q8WZ60, 621 residues long.
MolForge cross-references it against 0 known binders and
116 disease associations.
Target properties
| Protein name | Kelch-like protein 6 |
|---|
| UniProt accession | Q8WZ60 |
|---|
| Gene | KLHL6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 621 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (116)
Diseases linked to this target (Open Targets).
- non-Hodgkins lymphoma · score 0.37
- skin aging · score 0.28
- skin aging measurement · score 0.27
- monoclonal B-cell lymphocytosis · score 0.14
- SAPHO syndrome · score 0.13
- Okt4 epitope deficiency · score 0.09
- diffuse large B-cell lymphoma · score 0.08
- neutropenia, severe congenital, 2, autosomal dominant · score 0.08
- combined immunodeficiency with skin granulomas · score 0.07
- common variable immunodeficiency · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WZ60-F1 | alphafold | PREDICTED | 86.79 | — |
Amino-acid sequence (621 residues)
MLMAGQRGAW TMGDVVEKSL EGPLAPSTDE PSQKTGDLVE ILNGEKVKFD DAGLSLILQN GLETLRMENA LTDVILCVDI QEFSCHRVVL AAASNYFRAM FCNDLKEKYE KRIIIKGVDA ETMHTLLDYT YTSKALITKQ NVQRVLEAAN LFQFLRMVDA CASFLTEALN PENCVGILRL ADTHSLDSLK KQVQSYIIQN FVQILNSEEF LDLPVDTLHH ILKSDDLYVT EEAQVFETVM SWVRHKPSER LCLLPYVLEN VRLPLLDPWY FVETVEADPL IRQCPEVFPL LQEARMYHLS GNEIISERTK PRMHEFQSEV FMIIGGCTKD ERFVAEVTCL DPLRRSRLEV AKLPLTEHEL ESENKKWVEF ACVTLKNEVY ISGGKETQHD VWKYNSSINK WIQIEYLNIG RWRHKMVVLG GKVYVIGGFD GLQRINNVET YDPFHNCWSE AAPLLVHVSS FAATSHKKKL YVIGGGPNGK LATDKTQCYD PSTNKWSLKA AMPVEAKCIN AVSFRDRIYV VGGAMRALYA YSPLEDSWCL VTQLSHERAS CGIAPCNNRL YITGGRDEKN EVIATVLCWD PEAQKLTEEC VLPRGVSHHG SVTIRKSYTH IRRIVPGAVS V
Explore Kelch-like protein 6 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets