Delta-sarcoglycan (SGCD)

About Delta-sarcoglycan

Delta-sarcoglycan (SGCD) is a protein from Homo sapiens identified by UniProt accession Q92629, 289 residues long. MolForge cross-references it against 0 known binders and 298 disease associations.

Target properties

Protein name	Delta-sarcoglycan
UniProt accession	Q92629
Gene	SGCD
Organism	Homo sapiens
Length	289 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (298)

Diseases linked to this target (Open Targets).

autosomal recessive limb-girdle muscular dystrophy type 2F · score 0.76
dilated cardiomyopathy 1L · score 0.71
limb-girdle muscular dystrophy · score 0.66
autosomal recessive limb-girdle muscular dystrophy · score 0.48
Abnormality of the musculature · score 0.41
disease progression measurement · score 0.41
metastasis measurement · score 0.41
familial isolated dilated cardiomyopathy · score 0.38
neuromuscular disease · score 0.33
HOMA-B · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92629-F1	alphafold	PREDICTED	81.33	—

Amino-acid sequence (289 residues)

MPQEQYTHHR STMPGSVGPQ VYKVGIYGWR KRCLYFFVLL LMILILVNLA MTIWILKVMN FTIDGMGNLR ITEKGLKLEG DSEFLQPLYA KEIQSRPGNA LYFKSARNVT VNILNDQTKV LTQLITGPKA VEAYGKKFEV KTVSGKLLFS ADNNEVVVGA ERLRVLGAEG TVFPKSIETP NVRADPFKEL RLESPTRSLV MEAPKGVEIN AEAGNMEATC RTELRLESKD GEIKLDAAKI RLPRLPHGSY TPTGTRQKVF EICVCANGRL FLSQAGAGST CQINTSVCL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards