About Dual specificity tyrosine-phosphorylation-regulated kinase 2
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) is a protein
from Homo sapiens identified by UniProt accession
Q92630, 601 residues long.
MolForge cross-references it against 0 known binders and
196 disease associations.
Target properties
| Protein name | Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
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| UniProt accession | Q92630 |
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| Gene | DYRK2 |
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| Organism | Homo sapiens |
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| Length | 601 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (196)
Diseases linked to this target (Open Targets).
- body mass index · score 0.33
- cortical thickness · score 0.28
- cortical surface area measurement · score 0.28
- balding measurement · score 0.27
- breast adenocarcinoma · score 0.25
- neurofibrillary tangles measurement · score 0.24
- ovarian cancer · score 0.23
- brain measurement · score 0.22
- body height · score 0.22
- head and neck squamous cell carcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92630-F1 | alphafold | PREDICTED | 75.58 | — |
Amino-acid sequence (601 residues)
MLTRKPSAAA PAAYPTGRGG DSAVRQLQAS PGLGAGATRS GVGTGPPSPI ALPPLRASNA AAAAHTIGGS KHTMNDHLHV GSHAHGQIQV QQLFEDNSNK RTVLTTQPNG LTTVGKTGLP VVPERQLDSI HRRQGSSTSL KSMEGMGKVK ATPMTPEQAM KQYMQKLTAF EHHEIFSYPE IYFLGLNAKK RQGMTGGPNN GGYDDDQGSY VQVPHDHVAY RYEVLKVIGK GSFGQVVKAY DHKVHQHVAL KMVRNEKRFH RQAAEEIRIL EHLRKQDKDN TMNVIHMLEN FTFRNHICMT FELLSMNLYE LIKKNKFQGF SLPLVRKFAH SILQCLDALH KNRIIHCDLK PENILLKQQG RSGIKVIDFG SSCYEHQRVY TYIQSRFYRA PEVILGARYG MPIDMWSLGC ILAELLTGYP LLPGEDEGDQ LACMIELLGM PSQKLLDASK RAKNFVSSKG YPRYCTVTTL SDGSVVLNGG RSRRGKLRGP PESREWGNAL KGCDDPLFLD FLKQCLEWDP AVRMTPGQAL RHPWLRRRLP KPPTGEKTSV KRITESTGAI TSISKLPPPS SSASKLRTNL AQMTDANGNI QQRTVLPKLV S
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