About Nectin-2
Nectin-2 (NECTIN2) is a protein
from Homo sapiens identified by UniProt accession
Q92692, 538 residues long.
MolForge cross-references it against 0 known binders and
313 disease associations.
Target properties
| Protein name | Nectin-2 |
|---|
| UniProt accession | Q92692 |
|---|
| Gene | NECTIN2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 538 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (313)
Diseases linked to this target (Open Targets).
- Alzheimer disease · score 0.31
- low density lipoprotein cholesterol measurement · score 0.28
- family history of Alzheimer’s disease · score 0.28
- total cholesterol measurement · score 0.27
- mean platelet volume · score 0.24
- C-reactive protein measurement · score 0.23
- blood protein measurement · score 0.22
- mean corpuscular hemoglobin · score 0.20
- urate measurement · score 0.19
- serum metabolite measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92692-F1 | alphafold | PREDICTED | 75.77 | — |
Amino-acid sequence (538 residues)
MARAAALLPS RSPPTPLLWP LLLLLLLETG AQDVRVQVLP EVRGQLGGTV ELPCHLLPPV PGLYISLVTW QRPDAPANHQ NVAAFHPKMG PSFPSPKPGS ERLSFVSAKQ STGQDTEAEL QDATLALHGL TVEDEGNYTC EFATFPKGSV RGMTWLRVIA KPKNQAEAQK VTFSQDPTTV ALCISKEGRP PARISWLSSL DWEAKETQVS GTLAGTVTVT SRFTLVPSGR ADGVTVTCKV EHESFEEPAL IPVTLSVRYP PEVSISGYDD NWYLGRTDAT LSCDVRSNPE PTGYDWSTTS GTFPTSAVAQ GSQLVIHAVD SLFNTTFVCT VTNAVGMGRA EQVIFVRETP NTAGAGATGG IIGGIIAAII ATAVAATGIL ICRQQRKEQT LQGAEEDEDL EGPPSYKPPT PKAKLEAQEM PSQLFTLGAS EHSPLKTPYF DAGASCTEQE MPRYHELPTL EERSGPLHPG ATSLGSPIPV PPGPPAVEDV SLDLEDEEGE EEEEYLDKIN PIYDALSYSS PSDSYQGKGF VMSRAMYV
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