Synapsin-2 (SYN2)

About Synapsin-2

Synapsin-2 (SYN2) is a protein from Homo sapiens identified by UniProt accession Q92777, 582 residues long. MolForge cross-references it against 0 known binders and 181 disease associations.

Target properties

Protein name	Synapsin-2
UniProt accession	Q92777
Gene	SYN2
Organism	Homo sapiens
Length	582 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (181)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.42
schizophrenia · score 0.41
creatinine measurement · score 0.37
glomerular filtration rate · score 0.32
triglyceride measurement · score 0.28
platelet count · score 0.28
drug use measurement · score 0.28
psychiatric disorder · score 0.27
nervous system disease · score 0.27
eye disease · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92777-F1	alphafold	PREDICTED	73.90	—

Amino-acid sequence (582 residues)

MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQPPPPPPP GPGAASASAA PPTASPGPER RPPPASAPAP QPAPTPSVGS SFFSSLSQAV KQTAASAGLV DAPAPAPAAA RKAKVLLVVD EPHADWAKCF RGKKVLGDYD IKVEQAEFSE LNLVAHADGT YAVDMQVLRN GTKVVRSFRP DFVLIRQHAF GMAENEDFRH LIIGMQYAGL PSINSLESIY NFCDKPWVFA QLVAIYKTLG GEKFPLIEQT YYPNHKEMLT LPTFPVVVKI GHAHSGMGKV KVENHYDFQD IASVVALTQT YATAEPFIDS KYDIRVQKIG NNYKAYMRTS ISGNWKTNTG SAMLEQIAMS DRYKLWVDTC SEMFGGLDIC AVKAVHGKDG KDYIFEVMDC SMPLIGEHQV EDRQLITELV ISKMNQLLSR TPALSPQRPL TTQQPQSGTL KDPDSSKTPP QRPPPQGGPG QPQGMQPPGK VLPPRRLPPG PSLPPSSSSS SSSSSSAPQR PGGPTTHGDA PSSSSSLAEA QPPLAAPPQK PQPHPQLNKS QSLTNAFSFS ESSFFRSSAN EDEAKAETIR SLRKSFASLF SD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards