About Rho guanine nucleotide exchange factor 1
Rho guanine nucleotide exchange factor 1 (ARHGEF1) is a protein
from Homo sapiens identified by UniProt accession
Q92888, 912 residues long.
MolForge cross-references it against 0 known binders and
294 disease associations.
Target properties
| Protein name | Rho guanine nucleotide exchange factor 1 |
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| UniProt accession | Q92888 |
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| Gene | ARHGEF1 |
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| Organism | Homo sapiens |
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| Length | 912 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (294)
Diseases linked to this target (Open Targets).
- immunodeficiency 62 · score 0.58
- breast adenocarcinoma · score 0.18
- combined immunodeficiency with skin granulomas · score 0.08
- common variable immunodeficiency · score 0.08
- neutrophil immunodeficiency syndrome · score 0.07
- severe combined immunodeficiency due to CARD11 deficiency · score 0.07
- immunodeficiency 18 · score 0.07
- BENTA disease · score 0.07
- isolated agammaglobulinemia · score 0.07
- severe combined immunodeficiency due to CTPS1 deficiency · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92888-F1 | alphafold | PREDICTED | 73.19 | — |
Amino-acid sequence (912 residues)
MEDFARGAAS PGPSRPGLVP VSIIGAEDED FENELETNSE EQNSQFQSLE QVKRRPAHLM ALLQHVALQF EPGPLLCCLH ADMLGSLGPK EAKKAFLDFY HSFLEKTAVL RVPVPPNVAF ELDRTRADLI SEDVQRRFVQ EVVQSQQVAV GRQLEDFRSK RLMGMTPWEQ ELAQLEAWVG RDRASYEARE RHVAERLLMH LEEMQHTIST DEEKSAAVVN AIGLYMRHLG VRTKSGDKKS GRNFFRKKVM GNRRSDEPAK TKKGLSSILD AARWNRGEPQ VPDFRHLKAE VDAEKPGATD RKGGVGMPSR DRNIGAPGQD TPGVSLHPLS LDSPDREPGA DAPLELGDSS PQGPMSLESL APPESTDEGA ETESPEPGDE GEPGRSGLEL EPEEPPGWRE LVPPDTLHSL PKSQVKRQEV ISELLVTEAA HVRMLRVLHD LFFQPMAECL FFPLEELQNI FPSLDELIEV HSLFLDRLMK RRQESGYLIE EIGDVLLARF DGAEGSWFQK ISSRFCSRQS FALEQLKAKQ RKDPRFCAFV QEAESRPRCR RLQLKDMIPT EMQRLTKYPL LLQSIGQNTE EPTEREKVEL AAECCREILH HVNQAVRDME DLLRLKDYQR RLDLSHLRQS SDPMLSEFKN LDITKKKLVH EGPLTWRVTK DKAVEVHVLL LDDLLLLLQR QDERLLLKSH SRTLTPTPDG KTMLRPVLRL TSAMTREVAT DHKAFYVLFT WDQEAQIYEL VAQTVSERKN WCALITETAG SLKVPAPASR PKPRPSPSST REPLLSSSEN GNGGRETSPA DARTERILSD LLPFCRPGPE GQLAATALRK VLSLKQLLFP AEEDNGAGPP RDGDGVPGGG PLSPARTQEI QENLLSLEET MKQLEELEEE FCRLRPLLSQ LGGNSVPQPG CT
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