About Sodium/iodide cotransporter
Sodium/iodide cotransporter (SLC5A5) is a protein
from Homo sapiens identified by UniProt accession
Q92911, 643 residues long.
MolForge cross-references it against 0 known binders and
362 disease associations.
Target properties
| Protein name | Sodium/iodide cotransporter |
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| UniProt accession | Q92911 |
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| Gene | SLC5A5 |
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| Organism | Homo sapiens |
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| Length | 643 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (362)
Diseases linked to this target (Open Targets).
- familial thyroid dyshormonogenesis · score 0.63
- congenital hypothyroidism · score 0.46
- Goiter · score 0.37
- genetic disorder · score 0.19
- follicular thyroid adenoma · score 0.19
- lung adenocarcinoma · score 0.18
- cutaneous melanoma · score 0.18
- neoplasm · score 0.12
- Primary amenorrhea · score 0.12
- squamous cell lung carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92911-F1 | alphafold | PREDICTED | 81.32 | — |
Amino-acid sequence (643 residues)
MEAVETGERP TFGAWDYGVF ALMLLVSTGI GLWVGLARGG QRSAEDFFTG GRRLAALPVG LSLSASFMSA VQVLGVPSEA YRYGLKFLWM CLGQLLNSVL TALLFMPVFY RLGLTSTYEY LEMRFSRAVR LCGTLQYIVA TMLYTGIVIY APALILNQVT GLDIWASLLS TGIICTFYTA VGGMKAVVWT DVFQVVVMLS GFWVVLARGV MLVGGPRQVL TLAQNHSRIN LMDFNPDPRS RYTFWTFVVG GTLVWLSMYG VNQAQVQRYV ACRTEKQAKL ALLINQVGLF LIVSSAACCG IVMFVFYTDC DPLLLGRISA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG TLSTASTSIN AMAAVTVEDL IKPRLRSLAP RKLVIISKGL SLIYGSACLT VAALSSLLGG GVLQGSFTVM GVISGPLLGA FILGMFLPAC NTPGVLAGLG AGLALSLWVA LGATLYPPSE QTMRVLPSSA ARCVALSVNA SGLLDPALLP ANDSSRAPSS GMDASRPALA DSFYAISYLY YGALGTLTTV LCGALISCLT GPTKRSTLAP GLLWWDLARQ TASVAPKEEV AILDDNLVKG PEELPTGNKK PPGFLPTNED RLFFLGQKEL EGAGSWTPCV GHDGGRDQQE TNL
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