About DNA topoisomerase I, mitochondrial
DNA topoisomerase I, mitochondrial (TOP1MT) is a protein
from Homo sapiens identified by UniProt accession
Q969P6, 601 residues long.
MolForge cross-references it against 0 known binders and
125 disease associations.
Target properties
| Protein name | DNA topoisomerase I, mitochondrial |
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| UniProt accession | Q969P6 |
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| Gene | TOP1MT |
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| Organism | Homo sapiens |
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| Length | 601 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (125)
Diseases linked to this target (Open Targets).
- small cell lung carcinoma · score 0.58
- ovarian cancer · score 0.55
- carcinoma · score 0.48
- small cell carcinoma · score 0.47
- neuroblastoma · score 0.41
- cervical cancer · score 0.40
- acute myeloid leukemia · score 0.39
- lung cancer · score 0.39
- fallopian tube cancer · score 0.38
- sarcoma · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969P6-F1 | alphafold | PREDICTED | 90.75 | — |
Amino-acid sequence (601 residues)
MRVVRLLRLR AALTLLGEVP RRPASRGVPG SRRTQKGSGA RWEKEKHEDG VKWRQLEHKG PYFAPPYEPL PDGVRFFYEG RPVRLSVAAE EVATFYGRML DHEYTTKEVF RKNFFNDWRK EMAVEEREVI KSLDKCDFTE IHRYFVDKAA ARKVLSREEK QKLKEEAEKL QQEFGYCILD GHQEKIGNFK IEPPGLFRGR GDHPKMGMLK RRITPEDVVI NCSRDSKIPE PPAGHQWKEV RSDNTVTWLA AWTESVQNSI KYIMLNPCSK LKGETAWQKF ETARRLRGFV DEIRSQYRAD WKSREMKTRQ RAVALYFIDK LALRAGNEKE DGEAADTVGC CSLRVEHVQL HPEADGCQHV VEFDFLGKDC IRYYNRVPVE KPVYKNLQLF MENKDPRDDL FDRLTTTSLN KHLQELMDGL TAKVFRTYNA SITLQEQLRA LTRAEDSIAA KILSYNRANR VVAILCNHQR ATPSTFEKSM QNLQTKIQAK KEQVAEARAE LRRARAEHKA QGDGKSRSVL EKKRRLLEKL QEQLAQLSVQ ATDKEENKQV ALGTSKLNYL DPRISIAWCK RFRVPVEKIY SKTQRERFAW ALAMAGEDFE F
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