About Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma (PPP2R3C) is a protein
from Homo sapiens identified by UniProt accession
Q969Q6, 453 residues long.
MolForge cross-references it against 0 known binders and
67 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma |
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| UniProt accession | Q969Q6 |
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| Gene | PPP2R3C |
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| Organism | Homo sapiens |
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| Length | 453 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (67)
Diseases linked to this target (Open Targets).
- gonadal dysgenesis, dysmorphic facies, retinal dystrophy, and myopathy · score 0.65
- azoospermia · score 0.55
- neurodegenerative disease · score 0.51
- neutrophil count · score 0.30
- leukocyte count · score 0.26
- myeloid white cell count · score 0.24
- lean body mass · score 0.19
- monocyte percentage of leukocytes · score 0.13
- neutrophil percentage of leukocytes · score 0.13
- fat body mass · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969Q6-F1 | alphafold | PREDICTED | 89.91 | — |
Amino-acid sequence (453 residues)
MDWKEVLRRR LATPNTCPNK KKSEQELKDE EMDLFTKYYS EWKGGRKNTN EFYKTIPRFY YRLPAEDEVL LQKLREESRA VFLQRKSREL LDNEELQNLW FLLDKHQTPP MIGEEAMINY ENFLKVGEKA GAKCKQFFTA KVFAKLLHTD SYGRISIMQF FNYVMRKVWL HQTRIGLSLY DVAGQGYLRE SDLENYILEL IPTLPQLDGL EKSFYSFYVC TAVRKFFFFL DPLRTGKIKI QDILACSFLD DLLELRDEEL SKESQETNWF SAPSALRVYG QYLNLDKDHN GMLSKEELSR YGTATMTNVF LDRVFQECLT YDGEMDYKTY LDFVLALENR KEPAALQYIF KLLDIENKGY LNVFSLNYFF RAIQELMKIH GQDPVSFQDV KDEIFDMVKP KDPLKISLQD LINSNQGDTV TTILIDLNGF WTYENREALV ANDSENSADL DDT
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