About Protein TMEPAI
Protein TMEPAI (PMEPA1) is a protein
from Homo sapiens identified by UniProt accession
Q969W9, 287 residues long.
MolForge cross-references it against 0 known binders and
116 disease associations.
Target properties
| Protein name | Protein TMEPAI |
|---|
| UniProt accession | Q969W9 |
|---|
| Gene | PMEPA1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 287 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (116)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- vital capacity · score 0.28
- cortical thickness · score 0.26
- adolescent idiopathic scoliosis · score 0.24
- smoking status measurement · score 0.22
- thoracic aortic aneurysm · score 0.19
- flatfoot · score 0.18
- Tall stature · score 0.18
- Dolichocephaly · score 0.18
- Loeys-Dietz syndrome · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969W9-F1 | alphafold | PREDICTED | 56.71 | — |
Amino-acid sequence (287 residues)
MHRLMGVNST AAAAAGQPNV SCTCNCKRSL FQSMEITELE FVQIIIIVVV MMVMVVVITC LLSHYKLSAR SFISRHSQGR RREDALSSEG CLWPSESTVS GNGIPEPQVY APPRPTDRLA VPPFAQRERF HRFQPTYPYL QHEIDLPPTI SLSDGEEPPP YQGPCTLQLR DPEQQLELNR ESVRAPPNRT IFDSDLMDSA RLGGPCPPSS NSGISATCYG SGGRMEGPPP TYSEVIGHYP GSSFQHQQSS GPPSLLEGTR LHHTHIAPLE SAAIWSKEKD KQKGHPL
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