Terminal nucleotidyltransferase 5B (TENT5B)

About Terminal nucleotidyltransferase 5B

Terminal nucleotidyltransferase 5B (TENT5B) is a protein from Homo sapiens identified by UniProt accession Q96A09, 425 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.

Target properties

Protein name	Terminal nucleotidyltransferase 5B
UniProt accession	Q96A09
Gene	TENT5B
Organism	Homo sapiens
Length	425 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (56)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.24
vitamin D measurement · score 0.19
low density lipoprotein cholesterol measurement · score 0.15
leukocyte count · score 0.11
Hypercholesterolemia · score 0.09
reticulocyte count · score 0.07
testosterone measurement · score 0.06
sex hormone-binding globulin measurement · score 0.06
pachyonychia congenita · score 0.06
gout · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96A09-F1	alphafold	PREDICTED	81.82	—

Amino-acid sequence (425 residues)

MMPSESGAER RDRAAAQVGT AAATAVATAA PAGGGPDPEA LSAFPGRHLS GLSWPQVKRL DALLSEPIPI HGRGNFPTLS VQPRQIVQVV RSTLEEQGLH VHSVRLHGSA ASHVLHPESG LGYKDLDLVF RVDLRSEASF QLTKAVVLAC LLDFLPAGVS RAKITPLTLK EAYVQKLVKV CTDSDRWSLI SLSNKSGKNV ELKFVDSVRR QFEFSIDSFQ IILDSLLLFG QCSSTPMSEA FHPTVTGESL YGDFTEALEH LRHRVIATRS PEEIRGGGLL KYCHLLVRGF RPRPSTDVRA LQRYMCSRFF IDFPDLVEQR RTLERYLEAH FGGADAARRY ACLVTLHRVV NESTVCLMNH ERRQTLDLIA ALALQALAEQ GPAATAALAW RPPGTDGVVP ATVNYYVTPV QPLLAHAYPT WLPCN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards