Mitoferrin-2 (SLC25A28)

About Mitoferrin-2

Mitoferrin-2 (SLC25A28) is a protein from Homo sapiens identified by UniProt accession Q96A46, 364 residues long. MolForge cross-references it against 0 known binders and 164 disease associations.

Target properties

Protein name	Mitoferrin-2
UniProt accession	Q96A46
Gene	SLC25A28
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (164)

Diseases linked to this target (Open Targets).

colorectal cancer · score 0.35
digestive system cancer · score 0.30
cholelithiasis · score 0.18
calcium/calmodulin-dependent protein kinase type 1 measurement · score 0.15
diverticulitis · score 0.15
colorectal adenoma · score 0.14
diverticular disease · score 0.11
Fuchs endothelial corneal dystrophy · score 0.08
mean corpuscular volume · score 0.08
azoospermia · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96A46-F1	alphafold	PREDICTED	72.93	—

Amino-acid sequence (364 residues)

MELEGRGAGG VAGGPAAGPG RSPGESALLD GWLQRGVGRG AGGGEAGACR PPVRQDPDSG PDYEALPAGA TVTTHMVAGA VAGILEHCVM YPIDCVKTRM QSLQPDPAAR YRNVLEALWR IIRTEGLWRP MRGLNVTATG AGPAHALYFA CYEKLKKTLS DVIHPGGNSH IANGAAGCVA TLLHDAAMNP AEVVKQRMQM YNSPYHRVTD CVRAVWQNEG AGAFYRSYTT QLTMNVPFQA IHFMTYEFLQ EHFNPQRRYN PSSHVLSGAC AGAVAAAATT PLDVCKTLLN TQESLALNSH ITGHITGMAS AFRTVYQVGG VTAYFRGVQA RVIYQIPSTA IAWSVYEFFK YLITKRQEEW RAGK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards