Leucine-rich repeat-containing protein 59 (LRRC59)

About Leucine-rich repeat-containing protein 59

Leucine-rich repeat-containing protein 59 (LRRC59) is a protein from Homo sapiens identified by UniProt accession Q96AG4, 307 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 59
UniProt accession	Q96AG4
Gene	LRRC59
Organism	Homo sapiens
Length	307 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.35
cancer · score 0.08
lung adenocarcinoma · score 0.08
ulcerative colitis · score 0.08
breast cancer · score 0.07
oral squamous cell carcinoma · score 0.07
hepatocellular carcinoma · score 0.06
neoplasm · score 0.05
skin pigmentation · score 0.05
urinary bladder carcinoma · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96AG4-F1	alphafold	PREDICTED	87.68	—

Amino-acid sequence (307 residues)

MTKAGSKGGN LRDKLDGNEL DLSLSDLNEV PVKELAALPK ATILDLSCNK LTTLPSDFCG LTHLVKLDLS KNKLQQLPAD FGRLVNLQHL DLLNNKLVTL PVSFAQLKNL KWLDLKDNPL DPVLAKVAGD CLDEKQCKQC ANKVLQHMKA VQADQERERQ RRLEVEREAE KKREAKQRAK EAQERELRKR EKAEEKERRR KEYDALKAAK REQEKKPKKE ANQAPKSKSG SRPRKPPPRK HTRSWAVLKL LLLLLLFGVA GGLVACRVTE LQQQPLCTSV NTIYDNAVQG LRRHEILQWV LQTDSQQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards