About Transmembrane protein 143
Transmembrane protein 143 (TMEM143) is a protein
from Homo sapiens identified by UniProt accession
Q96AN5, 459 residues long.
MolForge cross-references it against 0 known binders and
3 disease associations.
Target properties
| Protein name | Transmembrane protein 143 |
|---|
| UniProt accession | Q96AN5 |
|---|
| Gene | TMEM143 |
|---|
| Organism | Homo sapiens |
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| Length | 459 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (3)
Diseases linked to this target (Open Targets).
- ulcerative colitis · score 0.00
- IGA glomerulonephritis · score 0.00
- cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96AN5-F1 | alphafold | PREDICTED | 81.08 | — |
Amino-acid sequence (459 residues)
MTVELWLRLR GKGLAMLHVT RGVWGSRVRV WPLLPALLGP PRALSSLAAK MGEYRKMWNP REPRDWAQQY RERFIPFSKE QLLRLLIQEF HSSPAEKAAL EAFSAHVDFC TLFHYHQILA RLQALYDPIN PDRETLDQPS LTDPQRLSNE QEVLRALEPL LAQANFSPLS EDTLAYALVV HHPQDEVQVT VNLDQYVYIH FWALGQRVGQ MPLKSSVGSR RGFFTKLPPA ERRYFKRVVL AARTKRGHLV LKSFKDTPLE GLEQLLPELK VRTPTLQRAL LNLMLVVSGV AIFVNVGMVV LTDLKVATSL LLLLFAIFMG LRASKMFGQR RSAQALELAH MLYYRSTSNN SELLSALALR AQDEHTKEAL LAHSFLARRP GGTQGSPEET SRWLRSEVEN WLLAKSGCEV TFNGTRALAH LQALTPSMGL YPPPGFPKLD PVAPITSEPP QATPSSNIS
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