Transmembrane protein 18 (TMEM18)

About Transmembrane protein 18

Transmembrane protein 18 (TMEM18) is a protein from Homo sapiens identified by UniProt accession Q96B42, 140 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.

Target properties

Protein name	Transmembrane protein 18
UniProt accession	Q96B42
Gene	TMEM18
Organism	Homo sapiens
Length	140 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (102)

Diseases linked to this target (Open Targets).

body mass index · score 0.45
lean body mass · score 0.44
obesity · score 0.42
type 2 diabetes mellitus · score 0.41
body fat percentage · score 0.40
physical activity measurement · score 0.40
fat body mass · score 0.39
hip circumference · score 0.39
body weight · score 0.39
waist circumference · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96B42-F1	alphafold	PREDICTED	89.58	—

Amino-acid sequence (140 residues)

MPSAFSVSSF PVSIPAVLTQ TDWTEPWLMG LATFHALCVL LTCLSSRSYR LQIGHFLCLV ILVYCAEYIN EAAAMNWRLF SKYQYFDSRG MFISIVFSAP LLVNAMIIVV MWVWKTLNVM TDLKNAQERR KEKKRRRKED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards