Repulsive guidance molecule A (RGMA)

About Repulsive guidance molecule A

Repulsive guidance molecule A (RGMA) is a protein from Homo sapiens identified by UniProt accession Q96B86, 450 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.

Target properties

Protein name	Repulsive guidance molecule A
UniProt accession	Q96B86
Gene	RGMA
Organism	Homo sapiens
Length	450 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (108)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.48
blood protein measurement · score 0.42
neurofibrillary tangles measurement · score 0.33
high density lipoprotein cholesterol measurement · score 0.33
sleep duration · score 0.33
opioid dependence · score 0.29
BMI-adjusted waist circumference · score 0.27
type 2 diabetes mellitus · score 0.27
Abnormality of refraction · score 0.23
PHF-tau measurement · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96B86-F1	alphafold	PREDICTED	78.58	—

Amino-acid sequence (450 residues)

MQPPRERLVV TGRAGWMGMG RGAGRSALGF WPTLAFLLCS FPAATSPCKI LKCNSEFWSA TSGSHAPASD DTPEFCAALR SYALCTRRTA RTCRGDLAYH SAVHGIEDLM SQHNCSKDGP TSQPRLRTLP PAGDSQERSD SPEICHYEKS FHKHSATPNY THCGLFGDPH LRTFTDRFQT CKVQGAWPLI DNNYLNVQVT NTPVLPGSAA TATSKLTIIF KNFQECVDQK VYQAEMDELP AAFVDGSKNG GDKHGANSLK ITEKVSGQHV EIQAKYIGTT IVVRQVGRYL TFAVRMPEEV VNAVEDWDSQ GLYLCLRGCP LNQQIDFQAF HTNAEGTGAR RLAAASPAPT APETFPYETA VAKCKEKLPV EDLYYQACVF DLLTTGDVNF TLAAYYALED VKMLHSNKDK LHLYERTRDL PGRAAAGLPL APRPLLGALV PLLALLPVFC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards