SPRY domain-containing SOCS box protein 1 (SPSB1)

About SPRY domain-containing SOCS box protein 1

SPRY domain-containing SOCS box protein 1 (SPSB1) is a protein from Homo sapiens identified by UniProt accession Q96BD6, 273 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.

Target properties

Protein name	SPRY domain-containing SOCS box protein 1
UniProt accession	Q96BD6
Gene	SPSB1
Organism	Homo sapiens
Length	273 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (61)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
eosinophil count · score 0.45
eosinophil percentage of leukocytes · score 0.41
body height · score 0.41
BMI-adjusted waist-hip ratio · score 0.39
BMI-adjusted waist circumference · score 0.38
vital capacity · score 0.38
asthma · score 0.38
pulse pressure measurement · score 0.37
Eczematoid dermatitis · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96BD6-F1	alphafold	PREDICTED	91.97	—

Amino-acid sequence (273 residues)

MGQKVTGGIK TVDMRDPTYR PLKQELQGLD YCKPTRLDLL LDMPPVSYDV QLLHSWNNND RSLNVFVKED DKLIFHRHPV AQSTDAIRGK VGYTRGLHVW QITWAMRQRG THAVVGVATA DAPLHSVGYT TLVGNNHESW GWDLGRNRLY HDGKNQPSKT YPAFLEPDET FIVPDSFLVA LDMDDGTLSF IVDGQYMGVA FRGLKGKKLY PVVSAVWGHC EIRMRYLNGL DPEPLPLMDL CRRSVRLALG RERLGEIHTL PLPASLKAYL LYQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards