About Calcium release-activated calcium channel protein 1
Calcium release-activated calcium channel protein 1 (ORAI1) is a protein
from Homo sapiens identified by UniProt accession
Q96D31, 301 residues long.
MolForge cross-references it against 0 known binders and
515 disease associations.
Target properties
| Protein name | Calcium release-activated calcium channel protein 1 |
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| UniProt accession | Q96D31 |
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| Gene | ORAI1 |
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| Organism | Homo sapiens |
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| Length | 301 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (515)
Diseases linked to this target (Open Targets).
- combined immunodeficiency due to ORAI1 deficiency · score 0.75
- myopathy, tubular aggregate, 2 · score 0.74
- combined immunodeficiency due to CRAC channel dysfunction · score 0.54
- combined immunodeficiency · score 0.46
- tubular aggregate myopathy · score 0.46
- Combined immunodeficiency · score 0.46
- T-B+ severe combined immunodeficiency · score 0.46
- Stormorken-Sjaastad-Langslet syndrome · score 0.37
- myopathy, tubular aggregate, 1 · score 0.37
- mean platelet volume · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96D31-F1 | alphafold | PREDICTED | 71.28 | — |
Amino-acid sequence (301 residues)
MHPEPAPPPS RSSPELPPSG GSTTSGSRRS RRRSGDGEPP GAPPPPPSAV TYPDWIGQSY SEVMSLNEHS MQALSWRKLY LSRAKLKASS RTSALLSGFA MVAMVEVQLD ADHDYPPGLL IAFSACTTVL VAVHLFALMI STCILPNIEA VSNVHNLNSV KESPHERMHR HIELAWAFST VIGTLLFLAE VVLLCWVKFL PLKKQPGQPR PTSKPPASGA AANVSTSGIT PGQAAAIAST TIMVPFGLIF IVFAVHFYRS LVSHKTDRQF QELNELAEFA RLQDQLDHRG DHPLTPGSHY A
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