60S ribosomal export protein NMD3 (NMD3)

About 60S ribosomal export protein NMD3

60S ribosomal export protein NMD3 (NMD3) is a protein from Homo sapiens identified by UniProt accession Q96D46, 503 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	60S ribosomal export protein NMD3
UniProt accession	Q96D46
Gene	NMD3
Organism	Homo sapiens
Length	503 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.48
self reported educational attainment · score 0.30
blood urea nitrogen measurement · score 0.23
chronotype measurement · score 0.17
prostate cancer · score 0.11
prostate carcinoma · score 0.11
Familial prostate cancer · score 0.11
risky sexual behaviour measurement · score 0.08
Parkinson disease · score 0.08
serum urea measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96D46-F1	alphafold	PREDICTED	86.39	—

Amino-acid sequence (503 residues)

MEYMAESTDR SPGHILCCEC GVPISPNPAN ICVACLRSKV DISQGIPKQV SISFCKQCQR YFQPPGTWIQ CALESRELLA LCLKKIKAPL SKVRLVDAGF VWTEPHSKRL KVKLTIQKEV MNGAILQQVF VVDYVVQSQM CGDCHRVEAK DFWKAVIQVR QKTLHKKTFY YLEQLILKYG MHQNTLRIKE IHDGLDFYYS SKQHAQKMVE FLQCTVPCRY KASQRLISQD IHSNTYNYKS TFSVEIVPIC KDNVVCLSPK LAQSLGNMNQ ICVCIRVTSA IHLIDPNTLQ VADIDGSTFW SHPFNSLCHP KQLEEFIVME CSIVQDIKRA AGAGMISKKH TLGEVWVQKT SEMNTDKQYF CRTHLGHLLN PGDLVLGFDL ANCNLNDEHV NKMNSDRVPD VVLIKKSYDR TKRQRRRNWK LKELAREREN MDTDDERQYQ DFLEDLEEDE AIRKNVNIYR DSAIPVESDT DDEGAPRISL AEMLEDLHIS QDATGEEGAS MLT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards