Leucine-rich repeat-containing protein 39 (LRRC39)

About Leucine-rich repeat-containing protein 39

Leucine-rich repeat-containing protein 39 (LRRC39) is a protein from Homo sapiens identified by UniProt accession Q96DD0, 335 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 39
UniProt accession	Q96DD0
Gene	LRRC39
Organism	Homo sapiens
Length	335 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.29
body height · score 0.09
retinoblastoma · score 0.03
gut microbiome measurement · score 0.03
cystic fibrosis · score 0.01
cardiomyopathy · score 0.01
oral squamous cell carcinoma · score 0.01
hereditary spastic paraplegia · score 0.00
pulmonary fibrosis · score 0.00
axial length measurement · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96DD0-F1	alphafold	PREDICTED	90.79	—

Amino-acid sequence (335 residues)

MTENVVCTGA VNAVKEVWEK RIKKLNEDLK REKEFQHKLV RIWEERVSLT KLREKVTRED GRVILKIEKE EWKTLPSSLL KLNQLQEWQL HRTGLLKIPE FIGRFQNLIV LDLSRNTISE IPPGIGLLTR LQELILSYNK IKTVPKELSN CASLEKLELA VNRDICDLPQ ELSNLLKLTH LDLSMNDFTT IPLAVLNMPA LEWLDMGSNK LEQLPDTIER MQNLHTLWLQ RNEITCLPQT ISNMKNLGTL VLSNNKLQDI PVCMEEMANL RFVNFRDNPL KLKVSLPPSE GTDEEEEREL FGLQFMHTYI QESRRRADHQ VNGSTTLPIS INTDG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards